Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K
Identifieur interne : 004929 ( Main/Exploration ); précédent : 004928; suivant : 004930Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K
Auteurs : T. Yamada [Canada] ; P. L. Mcgeer [Canada] ; K. G. Baimbridge [Canada] ; E. G. Mcgeer [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1990.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Calbindin, Calbindin 1, Calbindins, Cell Count, Cell Survival (physiology), Corpus Striatum (physiology), Dopamine (physiology), Dopaminergic neuron, Female, Human, Humans, Immunohistochemistry, Male, Middle Aged, Nerve Degeneration (physiology), Nerve Tissue Proteins (metabolism), Neural Pathways (physiology), Neurons (metabolism), Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Parkinson's disease, S100 Calcium Binding Protein G (metabolism), Strionigral degeneration, Substantia Nigra (metabolism), Substantia nigra.
- MESH :
- chemical , metabolism : Nerve Tissue Proteins, S100 Calcium Binding Protein G.
- chemical , physiology : Dopamine.
- chemical : Calbindin 1, Calbindins.
- metabolism : Neurons, Parkinson Disease, Substantia Nigra.
- physiology : Cell Survival, Corpus Striatum, Nerve Degeneration, Neural Pathways.
- physiopathology : Parkinson Disease.
- Aged, Aged, 80 and over, Cell Count, Female, Humans, Immunohistochemistry, Male, Middle Aged.
Abstract
Abstract: The distribution of calbindin-D28K (CaBP)-positive neurons was investigated by immunohistochemistry in 4 controls, 5 cases of Parkinson's disease and a single case of strionigral degeneration. CaBP-positive neurons were preferentially localized to the mediodorsal portion of the substantia nigra pars compacta (SNC) in the β layer, while CaBP-negative, melanin-positive neurons were concentrated in the ventrolateral SNC in the α layer. In Parkinson's disease and the case of strionigral degeneration, there was a relative sparing of the CaBP-positive neurons compared with CaBP-negative, pigmented neurons. These data imply that CaBP may confer some protection to SNC dopaminergic neurons against the pathological process which is responsible for Parkinson's disease and strionigral degeneration.
Url:
DOI: 10.1016/0006-8993(90)91236-A
Affiliations:
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V6T 1W5</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Baimbridge, K G" sort="Baimbridge, K G" uniqKey="Baimbridge K" first="K. G." last="Baimbridge">K. G. Baimbridge</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Mcgeer, E G" sort="Mcgeer, E G" uniqKey="Mcgeer E" first="E. G." last="Mcgeer">E. G. Mcgeer</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">526</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="303">303</biblScope><biblScope unit="page" to="307">307</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Calbindin</term><term>Calbindin 1</term><term>Calbindins</term><term>Cell Count</term><term>Cell Survival (physiology)</term><term>Corpus Striatum (physiology)</term><term>Dopamine (physiology)</term><term>Dopaminergic neuron</term><term>Female</term><term>Human</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Nerve Degeneration (physiology)</term><term>Nerve Tissue Proteins (metabolism)</term><term>Neural Pathways (physiology)</term><term>Neurons (metabolism)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson's disease</term><term>S100 Calcium Binding Protein G (metabolism)</term><term>Strionigral degeneration</term><term>Substantia Nigra (metabolism)</term><term>Substantia nigra</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nerve Tissue Proteins</term><term>S100 Calcium Binding Protein G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calbindin 1</term><term>Calbindins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Survival</term><term>Corpus Striatum</term><term>Nerve Degeneration</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cell Count</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The distribution of calbindin-D28K (CaBP)-positive neurons was investigated by immunohistochemistry in 4 controls, 5 cases of Parkinson's disease and a single case of strionigral degeneration. CaBP-positive neurons were preferentially localized to the mediodorsal portion of the substantia nigra pars compacta (SNC) in the β layer, while CaBP-negative, melanin-positive neurons were concentrated in the ventrolateral SNC in the α layer. In Parkinson's disease and the case of strionigral degeneration, there was a relative sparing of the CaBP-positive neurons compared with CaBP-negative, pigmented neurons. These data imply that CaBP may confer some protection to SNC dopaminergic neurons against the pathological process which is responsible for Parkinson's disease and strionigral degeneration.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Yamada, T" sort="Yamada, T" uniqKey="Yamada T" first="T." last="Yamada">T. Yamada</name></noRegion><name sortKey="Baimbridge, K G" sort="Baimbridge, K G" uniqKey="Baimbridge K" first="K. G." last="Baimbridge">K. G. Baimbridge</name><name sortKey="Mcgeer, E G" sort="Mcgeer, E G" uniqKey="Mcgeer E" first="E. G." last="Mcgeer">E. G. Mcgeer</name><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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